Experienced medicinal chemist with proven record of delivering quality API clinical candidates for atherosclerosis, infectious disease, allergy respiratory, inflammation, and cardiovascular therapies.Experienced medicinal chemist. Delivered 17 active pharmaceutical compounds into development with the most advanced currently in Phase 2 trials.Served 6 years on clinical development teams and co - chaired the HIV protease development team.Sustained record of delivering quality API clinical candidates for atherosclerosis, infectious disease, allergy respiratory, inflammation, and cardiovascular therapies.8 years of pharmaceutical discovery ma...

Pharmaceutical Consultant for Process Research and Development Including Production of Controlled Substances, API, Platinum and Terpene Chemistry and Asymmetric Synthesis.Pharmaceutical process research and development.Development of active pharmaceutical ingredients (API).Organic synthesis, including platinum chemistry, synthesis of controlled substances, cannabinoid, opioid and heterocyclic chemistry.Terpene chemistry, amino acid, carbohydrate chemistry, organometallic chemistry and asymmetric synthesis.Good manufacturing practice (GMP) for pharmaceuticals.Seventeen years of pharmaceutical process research and development.Research experi...

Cancer drug discovery and evaluation; drug pathway and drug mechanismsCancer drug discovery researcher with pharmaceutical industry and academic research experience in the field of cancer and autoimmune diseases.Research experience in various in vitro/in vivo cancer biology and molecular biological techniques such as; ELISA, siRNA, qPCR, Western Blot, Apoptosis, Cell-Cycle Analysis, microscopic techniques and in vitro angiogenesis.Pathway and drug mechanism analysis using PCR- arrays and si-RNA arrays.Inventor with 15 patent applications in the field of cancer drug discovery and novel p38 inhibitors as anti-autoimmune diseases agents, an...

Specialist in pharmaceutical research and development, synthesis and scale up of experiments, anti-cancer drugsBiotechnology and pharmaceutical research and development:Pharmaceutical process research and process development.Multi step organic drug synthesis: Route and reagent selections; literature and patent survey of synthetic routes; synthesis of API or API intermediate to ensure non infringing routes.Skilled at the use of Boron reagents.Drug discovery:Strategies for discovery of new Inotropic agents (synthesis of modified Adenosine Monophosphate) for heart failure.Discovery for synthesis of novel prodrug oligonucleotide for Cytarabi...

Neurobiologist Consultant: Central Nervous System, Spinal Cord Injury, Hemostasis, Thrombosis and Autoimmune DiseasesEight (8) years of experience in biotherapeutic drug discovery and development with a focus on neurobiology, hemostasis, thrombosis and autoimmune diseases.Drug discovery research for hemophilia and in critical bleeding indications.Development of therapeutics for spinal cord injury, multiple sclerosis and other central nervous system disorders.Experienced with molecular and cellular pharmacology, cell-based assays with central nervous system (CNS) and immune cell types, immunohistochemistry and thrombosis pathology, animal m...

Pharmaceutical Chemistry Consultant for Drug Discovery, ADME, and Drug Toxicity and Drug SafetyPharmaceutical drug discovery process and implementation.Drug discovery and medicinal chemistry.Preclinical pharmacology, ADME (absorption, distribution, metabolism, and excretion of drugs) and pharmaceutical toxicology and safety.Pharmaceutical drugs for anti-infectives, anti-virals, oncology and immunology.Pharmaceutical drugs for cardiovascular and metabolic disease.Pharmaceutical drugs for diabetes, obesity, aging and frailty.Due diligence assessments, including intellectual property.

Drug Portfolio Discovery, Development and Management ConsultantDrug discovery and innovation management with global pharmaceutical companies.Create and implement pharmaceutical research and development strategies and processes to deliver superior value.Develop and implement worldwide pharmaceutical portfolio management for GlaxoSmithKline discovery and genetics research businesses.Negotiations and implementation of processes for selection and prioritization of drug research programs.Enabled the increased productivity of drug leads in GSK by 50% in 2 years and reduced cycle times by 50%.

Consultant for Pharmaceutical Peptide Chemistry, Sterochemistry and Pharmaceutical Leads Testing and AnalysisTechnology transfer and business plan development.Marketing and contracts.Medicinal chemistry drug discovery.Catalytic methods to control stereochemistry.Pharmaceutical lead optimization and testing.Intellectual property management.Structure-based drug design.Peptide chemistry.Preclinical development.cGMP chemical process development.Preparation of CMC section of IND.Outsourcing and partnering of medicinal chemistry.Scientific proposal writing for government funding.

Oncology, Central Nervous System and Alzheimer's Disease Medicinal Chemist ConsultantMedicinal chemistry and target identification, preclinical lead compound development and small molecule drug discovery process.Expansion and lead optimization for protein structure based and whole cell-based optimization of compounds in therapeutic areas of oncology, CNS, (Central Nervous System) and Inflammation.Optimization for extra-cellular and intra-cellular molecular targets, e.g., GPCR's, CNS, and Kinases.Experience with agonist of human neuronal nAChRs, GABA, BACE as an allosteric modulators with potential of better control of CNS process.Discovery...

Chemical Synthesis Consultant of Natural Products for Medicinal ApplicationsSynthesis of natural products for medicinal applications.Understanding and cataloging of non-prescription drugs.Synthesis of aristolochic acid and derivatives.Synthesis of substituted indole-3-caboxamide compounds as local anesthetics.Photochemical synthesis of phenanthrenes.Synthesis of biotin analogs for biochemical enzymatic studies.Synthesis of anthracycline derivatives as anticancer drugs.Synthesis of novel heterocyclic ring systems as potential drugs.Education in medicinal chemistry and pharmacology.Poison ivy and poison oak remedies.