Log in

Login to your account

Username *
Password *
Remember Me
Loading...
Show More
Add this resume to contact form Yes No
Back to Search Result GO

Biotherapeutics & Nanobiotechnology: Drug Development in Brain Trauma, Alzheimer & Cancer: Expert & Consultant

Technical Consultant #2485


Expertise

 

  • Recombinant antibodies (scFv, Fab), immunotoxins and antibody-drug conjugates (ADC), targeting characterization and pre-clinical testing in animal models.
  • Expression, purification and characterization of biotherapeutics and testing in cancer xenografts in mice.
  • Combinatorial phage library screening in disease models of cancer, brain diseases (Alzheimer’s, Traumatic Brain Injury) and drug-resistant bacterial infections.
  • Transitional medicine with focus to protein therapeutics and nanobiotechnology.
  • Protein therapeutics and drug delivery working with internationally markets (Asia, Europe and U.S.A.).
  • Nanoparticle based targeted-drug delivery of chemotherapeutics and antisense oligonucleotides.
  • Supporting biotech startups developing peptide-targeted therapeutics for brain diseases.
  • Deliver cytotoxic payloads using antibody-targeted drug delivery systems.
  • Experimental design and analysis of treatment studies in relevant animal models.
  • Inventor of 4 patents on new class of metal-linkers for ADCs, supramolecular therapeutics and brain injury and infection targeting peptides.
  • Pharmaceutical drug development, project management and coordination of multi-disciplinary teams.
  • Recipient of NSF SBIR awards (Phase I & II) to develop novel agents for treating brain injuries.
  • Combinatorial peptide library screening by phage display, both in vitro and in vivo.
  • Pre-clinical cancer models (xenografts and orthotopic models).
  • CNS disease rodent models (Alzheimer's and Traumatic brain injury).
  • Drug-resistant bacterial infections (eg. MRSA), in vitro and animal models.
  • Novel peptide platforms for directed drug delivery to brain injury and CNS diseases.
  • Novel antibody-drug conjugates (ADCs), their characterization and pre-clinical testing.
  • Writing and securing Phase I and Phase II SBIR grants.

Experience

Undisclosed Company, CSO & Principle Investigator, 2016 - Present                                                                                                                                                                                                     

  • Lead multi-discipline early-stage projects from initial concept to lead optimization in the CNS and oncology area.
  • Developed novel peptides for directed delivery of therapeutics to brain injury using phage display.
  • Serve as a PI on NIH and NSF grants exceeding $1 million to conduct high-throughput screening to develop novel peptide mimetics for TBI therapy. Inventor on patents on novel peptides as diagnostic and therapeutic targeting platform.
  • Presented experimental data in international meetings, published scientific work in high impact journals.
  • Project management, solving problems, overseeing operations as well as engaging in high-level discussions with potential pharma partners.
  • Identified novel targeting peptides that specifically recognize, a peptide technology platform bringing transformative advances into the treatment of TBI, positively impact the lives of injury victims.

SBPMD, Research, 2014 - Present

Research Assistant Professor & Research Specialist

  • Part of a multi-center DARPA contract to develop innovative tools for targeted-delivery of nanoparticles for therapy of neurodegenerative diseases such as Alzheimer’s (AD) and infectious diseases.
  • Work included in vivo phage-display to screen peptide libraries, identifying new biomarkers, testing the target engagement of new peptides in pre-clinical models of AD and bacterial infections.
  • Identified newly peptide probes used for imaging early AD and delivery of therapeutics with nanoparticles.
  • Targeted delivery of anti-infectives to the site of bacterial infection: Bacterial resistance to antibiotics has made it necessary to resort to antibiotics that have considerable toxicities.
  • Employed in vivo phage screening in mice with S. aureus-induced lung infections and identified peptides that can deliver antibiotics via peptide-targeted nanoparticles.
  • Collaborated with material engineers and chemists and developed a targeted-antibiotic delivery with enhanced anti-bacterial efficacy, minimizing drug dose and side effects.
  • Therapeutic delivery of antibiotic-carrying nanoparticles to drug-resistant infections has been published in top tier journals.

Postdoctoral Fellow, 2008 - 2011

  • Novel Biomarker Discovery in Metastatic Breast Cancer: Screened peptide libraries using in vivo phage display technology, successfully identified peptides that home to the pre-metastatic niches in malignant breast tumors.
  • New targeting ligands and biomarkers were characterized for detecting cancer metastasis at an early stage.
  • Quantitative Assays: Developed a method for the in vivo quantitation of tumor-associated antigens in xenografts published in Scientific Reports. This method has demonstrated its utility in overcoming the limitations of receptor saturation in drug-delivery applications.

Invictus Oncology, New Delhi, India, Scientist II (Project Leader), 2011 - 2014

  • Development of antibody-drug conjugates (ADC) for the therapy of solid tumors.
  • As Project Lead oversaw multidisciplinary teams to develop novel ADCs to deliver cytotoxic payloads to solid tumors.
  • Successfully secured grants to establish the platform technology, supervised junior scientists, managed 2 projects, and established the protein chemistry laboratory infrastructure.
  • Work resulted in a high impact publication and also contributed to the IP portfolio worldwide patent.
  • Nanoparticle based delivery of platinum-agents for cancer therapy: Developed new platinum-agents and formulations for drug delivery.
  • Enhanced efficacy and reduced unspecific toxicity in pre-clinical studies resulting in one provisional patent.
  • Novel platinum-agents have undergoing scale up for a clinical trial.

MD Anderson Cancer Center, Houston, TX, Postdoctoral Associate, 2008

Experimental Therapeutics

  • Therapeutic payload development: In collaboration with Targa Therapeutics, worked with a team that successfully developed Granzyme B-based immunotoxins for cancer therapy.

University of Zurich, Biochemistry Institute, Switzerland, Doctoral Studies, 2001 - 2007

  • Targeted drug delivery: Designed and generated antibody-guided nanoparticles for site-specific delivery of drugs, and antisense oligonucleotides to tumor cells.
  • Demonstrated superior cytotoxic activity, improve pharmacokinetics, biodistribution and efficacy in xenograft animal models.
  • Immunoconjugates for cancer therapy: Involved in the expression, purification and therapeutic application of recombinant single-chain (scFv) antibody and fusion toxins (immunoconjugates) for the therapy of solid tumors.

Honors & Publications


Languages 

  • English
  • German (basic)

Publications and Patents 

  • Author-Co-Author of domestic and international peer reviewed journals, periodicals and Symposia Host
  • Inventor and Co-Inventor of 4 patents on new class of metal-linkers for ADCs, supramolecular therapeutics and brain injury and infection targeting peptides.

Education

  • Ph.D.   Biochemistry, University of Zurich, Zurich, Switzerland
  • M.S.     Biochemistry, Aligarh Muslim University, Aligarh, India
  • B.S.       Biochemistry, Aligarh Muslim University, Aligarh, India
Back to Search Result GO