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Biominformatics and Biomechanics Design Consultant

Technical Consultant #2436


Expertise

  • Bioinformatics research projects, involving external collaborators with industry and core facilities.
  • Biomechanics and design biomarker studies. Analyze and review data in drug discovery and drug development.
  • Analyze novel signaling pathways that modulate osteoclast functions.
  • Develop inhibitors for the treatment of autoimmune diseases.
  • Regenerative medicine research.
  • In-vivo research utilizing rodent models of bone disease including knock-out, transgenics, overexpression and various animal models of arthritis as well as in-vitro cell-based assays to delineate the immune regulation of bone loss in rheumatoid arthritis.
  • Rheumatic diseases, cellular and molecular mechanisms of pathological bone loss.
  • Conduct laboratory studies of the interface between the skeletal and immune systems, a newly emerging area of research called "osteoimmunology."
  • Through in-vivo gene transfer of immune cytokines IL-23 and IL-17, established new arthritis animal models that highlight the importance of these immune cytokines in arthritis initiation and bone homeostasis.
  • Using in vitro assays, to define the cellular and molecular mechanisms that take place and interplay of the immune and skeletal systems.
  • Leukotriene B4 studies-activities in Juvenile Arthritis (JA).
  • Autophagy in skeletal development; identified protein domains associated with vesicle trafficking that impact bone destruction.

Experience

Undisclosed Hospital for Children, 2011 - Present

  • Associate Investigator, regenerative medicine and pediatrics, 2015 - Present
  • Assistant Investigator, regenerative medicine and pediatrics, 2011 - 2015

School of Medicine, University of California at Davis, 2010 - 2015

Associate Professor

  • Tenured/Tenure-Track (FTE) Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology.

Assistant Professor, 2010 - 2015

  • Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine.

DNAX Research Institute, Drug Discovery Research, Department of Immunology, 2007 - 2010

Post-Doctoral Research, Schering-Plough Biopharma, Laboratory

  • In-vivo research utilizing rodent models of bone disease including knock-out, transgenics, overexpression and various animal models of arthritis as well as in-vitro cell-based assays to delineate the immune regulation of bone loss in rheumatoid arthritis.

Washington University, St. Louis, Missouri, 2006 - 2007

Post-Doctoral Research, Department of Pathology and Immunology, Laboratory

  • Analyzed novel signaling pathways that modulate osteoclast function.

Biovista Inc., Greece, Consultant, 2002 - 2003

  • Advisor in Cell Signaling for, a global drug development services company that supplies corporate intelligence products and services to the life sciences industry.

University of Athens, Department of Biology, Greece, 1997 - 1999

  • Lecturer and Researcher,
  • Division of cell biology and biophysics.

Management

  • Manage a research laboratory staff, with $500K annual budget and multiple research projects, involving external collaborators with industry and core facilities including bioinformatics.
  • Outsource biomechanics and design biomarker studies for multiple projects. Analyze and review data in drug discovery/ development meetings.
  • Design and develop 'Osteo-Pro', a pioneering image processing software for quantifying bone lacunar resorption, spearheading project from inception to product development.
  • Manage the day-to-day running of the Pathological Bone Resorption Laboratory at the Botnar Research Center and supervise technical research assistants.
  • Project Management course, Medical Sciences Division, University of Oxford.
  • Wolfson College Academic Committee member. Plan and organize educational seminars of distinguished scientists.

Educator

  • Topics in Rheumatology & Clinical Immunology
  • Biomedical Engineering-Graduate Course
  • Clinical Immunology-Graduate students
  • Topics in Immunology-Graduate students
  • Comparative Clinical Immunology-Graduate students
  • Research-Autoimmune Disorders-Graduate students
  • Generating functional human osteoclasts'-International postgraduate course.
  • Introduction to cell biology
  • Introduction to cell microscopy
  • Certificate of Building a Business, course included a series of lectures on starting a company, raising capital, intellectual property management, product development and financial reporting.
  • Laboratory rotations of pre-doctoral graduate students at UC Davis

Examiner (Graduates)

  • Immunology
  • Comparative Pathology
  • Biochemistry, Molecular, Cellular & Developmental Biology
  • Pilot and Feasibility studies (P30 Musculoskeletal), Research Center at Washington University.

Honors & Publications


Credentials

  • Certificate of Proficiency in English, University of Cambridge

Thesis

  • Cellular and molecular mechanisms in pathological bone destruction in arthritis, University of Oxford
  • The effects of dexamethasone on enzyme regulation in human hepatocytes, University College Medical School, London.

Academic and Professional Affiliations

  • British Biochemical Society
  • American Society of Bone and Mineral Research
  • British Society for Research Into Aging
  • American Association of Immunologists
  • International Cytokine Society (ICS)
  • International Society for Interferon and Cytokine Research
  • Elected Member Childhood Arthritis and Rheumatology Research Alliance
  • American College of Rheumatology (ACR).

Publications

  • Author of many publications in peer reviewed journals, presentations, conference papers, educational text and invited speaker, tackling subjects such as: Arthritis, Rheumatism, Immunology, Autoimmunity, Orthopedic Research, Biologics.

Education

  • D.Phil. Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
  • M.Phil. Clinical Medicine (Hepatology), University of London, London, United Kingdom
  • B.Sc. Medical Microbiology (With Honors), University of Surrey, Guildford, United Kingdom
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