Ph.D. Inorganic Chemist Specializing in Electrochemistry, with Development Expertise for In Vitro Biosensor Technology Sector of Medical Diagnostics

Technical Consultant #1767

Electrochemistry medical diagnostics.
Electrochemical detection technology.
Development know how in in vitro diagnostics including electrochemical sensors and biosensors.
Chemical sensor technology for Homeland Security Applications.
Developing medical and scientific products from concept-to-market.

Independent Contractor, Present

Undisclosed Company, Vice President, Biosensor Technology, 2007 - 2010

Leader of biosensor technology sector of medical diagnostic company: Head of Research and Development for in vitro diagnostic (IVD) tests; manage Research and Development Group.
Led the technical evaluation effort for purchase of Alderon Biosciences by Magellan, assessed intellectual property and assets.
Generated market research report on point-of-care IVDs for company strategic planning: potential markets of over $15 million for IVDs with electrochemical detection technology.
Established technical and manufacturing feasibility of an enzyme based point of care IVD using a disposable electrochemical sensor.
Developed list of viable product-lines for company to extend existing products and tests for future growth based on research and development for dual-use sensors and automated blood lead testing.

Technical Consultant, Arlington, MA, 2006 - 2007

Led technical assessment of biosensor and related technologies for firms focused on medical in vitro diagnostic testing products.
Evaluations used as part of strategic acquisitions and licensing arrangements.

Sionex Corporation, Bedford, MA, Sr. Director of Applications, 2004 - 2006

Director of the Applications Department for an early stage company focused on development of breakthrough chemical sensor chips for emerging markets including Defense and Homeland Security.
Led a cross-departmental technical team as Program Manager for three government contracts:
Homeland Security's ARFCAM - building monitor for HVAC use; contract award $600,000.
Homeland Security's LACIS - portable first responder chemical detector; contract award $750,000.
DARPA contract for sensor chip improvements; contract award $110,000.
Directed application team in the development of a small, handheld gas chromatograph - differential mobility detector (GC-DMS) for use in chemical warfare agent detection, toxic industrial chemical analyses, and detection and identification of biological species.
Directed and participated in sensor chip system improvements in expanding the number of explosive compounds that could be detected in the Thermo Electron Corporation Egis™ Defender.

ESA Inc., Chelmsford, MA, Director of Development, 1991 - 2004

Manager Sensor Development, 1989 - 1991
Scientist, 1988 - 1989

As the Director of the Engineering Division for analytical instrument company, responsible for research and development for new and existing products in analytical instrumentation, including electrochemical (EC) detectors for high performance liquid chromatography (HPLC) and medical device blood lead detectors.
Led the team that developed a research and development 100 award-winning charged aerosol detector (Corona® CAD™), which is a unique, universal detector technology for HPLC.
Managed chemistry/engineering team of 12 that developed an HPLC-EC detector for half of the production costs and one quarter the size of previous model while significantly improving sensitivity. Detector development was on budget, on schedule, and met target costs.
Directed the detector software development and regulatory compliance with 21 CFR part 11. Resulted in increased product sales of more than 100%.
Principal investigator and project manager, Centers for Disease Control and Prevention (CDC) contract:
Developed CLIA "waived" point-of-care blood lead analyzer (joint research and development venture). Project resulted in a marketed portable, hand-held blood lead analyzer using disposable electrodes for physician offices.
Product gained company $10 million in new business (growth of 20%) in an overall declining blood lead testing market place.

Cambridge Research Laboratory, MA, Senior Scientist, Diagnostic Technologies, 1986 - 1988

Managed research and development team that developed novel biosensor for immunoassay resulting in new product line at this Johnson & Johnson subsidiary.
Research and development on disposable sensors for the ChemPro 1000 point of care chemistry analyzer including ISEs (ion-selective electrodes).
Saved millions of dollars in biosensor production costs by eliminating waste through the development and application of a new spraying system for precisely applying a biological reagent during sensor production.
Research and development on biosensors and DNA probes using amperometry, potentiometry, and electrogenerated chemiluminescence.
Additional research conducted in hematology and human T-cells.

GTE Laboratories, Waltham, MA, Member of the Technical Staff, 1985 - 1986

Conceived, supervised, and performed experiments leading to the site-specific attachment of an enzyme-cofactor to electrode surfaces, resulting in the issuing of patents and publications vital to the future development of a generic biosensor.
Discovered a novel electrochemically-modified glassy carbon electrode with applications in material science of carbon composites.

California Institute of Technology, Pasadena, CA, Postdoctoral Fellow, 1982 - 1985

Conceived and conducted electrochemical studies of oxygen reduction catalyzed by cobalt(II) macrocycles.
Examined mechanisms and rate constants using rotating disk and rotating ring-disk voltammetry with computer simulations.
Developed and programmed (FORTRAN) an explicit-finite-difference simulation for the rotating.

Academic and Professional Affiliations

Publications and Patents