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Medicinal Chemistry Consultant Specializing in Drug Discovery, Process Research and Development, Organic Synthesis, cGMP, Chemical Hygiene and Lab Safety, EPA, OSHA Compliance

Technical Consultant #1746


  • Medicinal chemistry, process research and development, and organic synthesis.
  • Drug discovery, including small molecule structure-based design and SAR optimization in collaboration with CADD, biology, ADMET, and informatics teams.
  • Design and synthesis of complex organic compounds for medicinal applications.
  • Rational, structure-based drug design and development.
  • Design and execution of optimized, scalable, safe chemical processes for drug intermediates and APIs at multi-kilogram scales.
  • Synthesis of substituted aromatics, aliphatics, heterocycles, fluorinated analogs, oligopeptides, cyclic peptides, peptidomimetics, organosilanes, organometallics, chiral compounds and inorganics.
  • cGMP synthesis and FDA documentation.
  • Kinase inhibitors.
  • PARP inhibitors.
  • Cysteine protease inhibitors.
  • Angiotensin receptor antagonists.
  • Glycoprotein IIb/IIIa (GP2b3a) receptor antagonists.
  • NSAIDs.
  • IP due diligence.
  • Chemical Hygiene and Laboratory Safety; EPA, OSHA compliance.
  • Hands-on expertise with the latest computer-integrated analytical and preparative instrumentation, including multi-probe high-field NMR, FT-IR, LC-MS, HPLC, MPLC (ISCO), and RP-HPLC (Gilson).


Undisclosed Company, Senior Scientist, 1994 - 2010

  • Drug Discovery Group Leader, Medicinal Chemistry Department.
  • Supervised technical and professional staff within multi-disciplinary teams.
  • Discovered and developed novel, patented kinase inhibitors (ALK, cMet, JAK).
  • Discovered and developed novel, patented PARP-1 inhibitors; co-inventor of CEP-9722, in clinical trials for adjuvant cancer therapy.
  • Invented and developed 1,2-Benzothiazine-1,1-dioxides, a patented NCE for Calpain-1 inhibitors as potential stroke therapy.
  • Invented novel, patented Calpain-1 peptidomimetic inhibitors.
  • Chemical Hygiene Manager, Laboratory Safety, EPA and OSHA compliance.

E. I. DuPont de Nemours & Co. Wilmington, DE, 1984 - 1994

  • As Scientist and Senior Scientist at DuPont-Merck Pharmaceutical Co., Experimental Station Laboratory;
  • Co-invented Losartan (Cozaar®), a blockbuster first-in-class all receptor antagonist for treatment of hypertension.
  • Co-developed an optimized synthetic process for Losartan; co-managed synthesis of pre-clinical supplies.
  • Discovered and developed cyclic peptides as glycoprotein IIb/IIIa (GP2b3a) receptor antagonists for potential antiplatelet medication.
  • Process Research and Development Group Leader and Supervisor.
  • Designed and optimized chemical process for NSAID clinical candidate, DuP-697.
  • Delivered multi-kilogram cGMP and non-GMP supplies of various APIs and intermediates under deadline and budget for several pre-clinical and clinical candidates.
  • Consulted vendor CRO for related activities.

Merck, Sharpe and Dohme & Co., Rahway, NJ, Research Chemist, 1979 - 1980

  • Angiotensin Converting Enzyme (ACE) inhibitors; synthesized peptidomimetics and contributed to SAR activities helping lead to Enalapril®, a blockbuster drug for treatment of hypertension.

Honors & Publications

Academic and Professional Affiliations

  • American Chemical Society - Medicinal Chemistry Division, Organic Chemistry Division

Publications and Patents

  • Over 30 peer reviewed publications.
  • 14 drug discovery related patents.
  • Various presentations at local and national conferences.


  • Ph.D. Organic Chemistry, Ohio State University, Columbus, OH
  • M.S. Organic Chemistry, Ohio State University, Columbus, OH
  • B.S. Chemistry (With Honors), Susquehanna University, Selinsgrove, PA
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