Protein Engineering and DNA Repair Expert Specializing in Directed Enzyme Evolution
Technical Consultant #1633
- Random mutant library generation.
- Protein engineering.
- Mutagenicity assays, (Ames' test).
- ColE1-based plasmid regulation.
- DNA repair, specifically repair of reactive DNA methylation.
- Drug resistance: targets, evolution.
- Microbial genetics.
- Molecular pharmacology.
- Molecular toxicology.
Undisclosed University, Assistant Professor, 2007 - Present
- Head of a research team including a senior scientist, technician, graduate student and several undergraduate assistants.
- Obtained extramural funding from NIH and private foundations.
- Ongoing interdisciplinary collaborations in areas of computational biology, chemistry and structural biology.
- Partnership with industry (Environmental Biodetection Products Inc.) for bringing new mutagenesis detection technology into the market.
- Teaching in areas of molecular toxicology and pathogenesis.
University of Washington, Seattle, WA, 2001 - 2007
- Acting Instructor: Applied directed evolution methods for customization of DNA methylation repair.
- Postdoctoral Fellow: Developed a proprietary system for directed protein evolution.
Stanford University School of Medicine, Microbiology and Immunology, Stanford, CA, 1994 - 2001
- Graduate Research Assistant
University of Barcelona, Department Biochemistry/Autonomous, Bellaterra, Spain, 1991 - 1994
- Masters Research Assistant/Mentor
- Undergraduate Research Assistant/Mentor
- Classes: Biology of Disease, Interdisciplinary approaches in microbiology and environmental toxicology.
Honors & Publications
Honors and Awards
- CONCERN Foundation Award for cancer research: Title, "Customizing DNA Repair to Reduce the Side Effects of Temozolomide."
- National Cancer Institute K08 award (top priority score of 117): Title, "Creation of AlkB Mutants for Bone Marrow Protection."
- Environmental Pathology/Toxicology Training Grant (T32 NIEHS National Research Service Award Program).
- Stanford Dean of Research Incentive Fund Award.
- "la Caixa" Fellowship, participant of the Fullbright program in Spain.
- Top Student of Graduating Class of Veterinary School of the Autonomous University of Barcelona, Bellaterra, Spain.
- Memberships: Environmental Mutagen Society, Society of Toxicology
- Editorial board: Theoretical Biology Insights
- Referee: Cellular and Molecular Life Sciences, Journal of Molecular Evolution
- Doctor in Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain
- Numerous invited talks, selected meeting presentations and articles published.
- Two U.S. Patents.
- Ph.D. Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
- M.S. Biochemistry, Autonomous University of Barcelona, Bellaterra, Spain