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Neurobiologist Consultant for Biotherapeutic Drug Discovery and Development

Technical Consultant #1490


Expertise

  • Eight (8) years of experience in biotherapeutic drug discovery and development with a focus on neurobiology, hemostasis, thrombosis and autoimmune diseases.
  • Drug discovery research for hemophilia and in critical bleeding indications.
  • Development of therapeutics for spinal cord injury, multiple sclerosis and other central nervous system disorders.
  • Experienced with molecular and cellular pharmacology, cell-based assays with central nervous system (CNS) and immune cell types, immunohistochemistry and thrombosis pathology, animal models.

Experience

Undisclosed Company, Manager, Molecular Pharmacology, 2007 - Present

  • Focus on drug discovery research for hemophilia and in critical bleeding disorders: Leader of tissue biology section.
  • Managed and supervised histology and cell biological studies.
  • Managed research contracts with academic collaborators testing neuroprotective compound for stroke and traumatic brain injury.

Staff Scientist, 2005 - 2006

  • Managed preclinical discovery project.
  • Performed in vitro testing of neuroprotective compounds.
  • Coordinated animal testing with external collaborators.

Acorda Therapeutics, Scientist, Hawthorne, NY, 1999 - 2005

  • Start-up biotech company specializing in the development of therapeutics for spinal cord injury, multiple sclerosis and other central nervous system disorders.
  • Led multidisciplinary teams conducting animal models for multiple sclerosis and spinal cord injury, pharmacological testing, biological assays and analytical characterization.
  • Worked with consultants and CROs in defining toxicology studies for FDA approval of therapeutic.
  • Coordinated research with academic and corporate collaborators.
  • Interacted with patent attorneys for due diligence analysis.
  • Supported drug discovery and development efforts by designing and implementing numerous functional assays.
  • Established cell-based assays for pre-clinical testing of drug candidates.
  • Designed and implemented tests for anti-inflammatory compound, including cytokine analysis.
  • Prepared technical reports and SOPs for pre-clinical projects.

The Rockefeller University, Research Associate, 1993 - 1998

  • Contributed to the understanding of basic principles underlying cellular specification in the developing mouse cerebellum.
  • Characterized the functional consequences of a mutant K channel in mouse cerebellar granule cells.
  • Conducted primary neuronal and non-neuronal cell culture.
  • Applied the technique of SAGE (Serial Analysis of Gene Expression) to analyze cerebellar gene expression during development.
  • Used a variety of molecular techniques including DNA cloning, DNA purification, PCR , Sequence analysis using BLAST.

Yale University, Postdoctoral Associate, 1991 - 1993

  • Studied developmental synaptic plasticity in the rodent CNS.
  • Analyzed the regulation of glutamate receptor genes during the development of the rat visual system.
  • Conducted DNA cloning, DNA purification, Northern blot analysis, RT-PCR, in situ hybridization.
  • Performed primary neuronal cultures.

Honors & Publications


Academic and Professional Affiliations

  • EMBO Long-Term Postdoctoral Fellowship

Publications

  • Authored many publications.

Education

  • Ph.D., Neurobiology, Max-Planck Institute for Psychiatry, Munich, Germany
  • B.S., Biology, Technical University, Munich, Germany
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