- Pulmonary fibrosis and pulmonary pathology.
- Lung diseases such as asthma and bronchitis.
- Environmental lung disease.
- Metal toxicity, vanadium toxicity.
- Carbon nanotube pulmonary toxicity.
- Occupational lung disease.
- Air pollution particles and associated lung disease.
- Cellular and molecular mechanisms of pulmonary fibrosis and chronic airway remodeling in asthma and bronchitis.
- Disruption of intracellular signaling pathways by air pollution particulate matter and metal-induced oxidative stress, particularly vanadium pentoxide.
- Pulmonary responses to manufactured carbon nanotubes and nanoparticles.
- Epithelial-fibroblast interactions in mediating airway remodeling and fibrosis.
- Growth factor receptor tyrosine kinases and their role in lung fibroblast proliferation, apoptosis, and cytokine production.
- Control of growth factor activity by extracellular cytokine-binding proteins.
- Strategies for the intervention of pulmonary fibrosis.
Undisclosed University, Present
- As Associate Professor studying the cellular and molecular mechanisms through which toxic environmental agents such as particles, nanoparticles, and metals cause fibroblast growth or matrix production resulting in fibrosis.
- Utilizing molecular techniques in genomics and transgenic mouse models, identified intracellular signaling pathways and novel genes that contribute to the progression of fibrosis.
- Research focus on two families of cell surface growth factor receptor tyrosine kinases (RTK) that mediate these cellular responses: the platelet-derived growth factor receptor family (PDGFR) and the epidermal growth factor receptor family (EGFR).
- Identified these RTKs as potentially important targets for therapeutic intervention of pulmonary fibrosis.
- New initiatives in nanotechnology aimed at understanding the possible health effects of manufactured nanomaterials (carbon nanotubes and nano-sized metal catalysts).
- Determine the physico-chemical properties of nanomaterials that trigger fibrotic reactions in the lung in order to provide information for the design of safer nanomaterials.
- Particular interest is determining the fibrotic potential of nanomaterials in mouse models of pre-existing lung disease such as asthma, viral infection, and bacterial endotoxin-induced inflammation.
- Lung fibrosis, asthma, nanotoxicology, metals, particles, fibers and microbial infections.
CIIT Centers for Health Research, Research Triangle Park, NC, 2004 - 2010
- Associate Investigator
National Institute of Environmental Health Sciences, Research Triangle Park, NC, 1990 - 2004
- Head, Airway Inflammation Group, 1993 - 2004
Laboratory of Pulmonary Pathobiology
- Staff Fellow and Senior Staff Fellow, 1990 - 1995
Adjunct Faculty Positions
- Adjunct Associate Professor of Pathology, Duke University, Durham, NC
- Adjunct Associate Professor, North Carolina State University, Raleigh, NC
North Carolina State University
Department of Toxicology
- Graduate Level Biochemical Toxicology 710 Biochemical Toxicology Course; lecture on "Respiratory Cell and Molecular Toxicology." 701 Introductory Toxicology Course, lecture to undergraduates on "Basic Principles of Respiratory Toxicology."
Veterinary Medical Sciences
- 570 Cell Biology Course, Department of Anatomy, College of Veterinary Medicine; lecture on "Growth Factors in Health and Disease".
- Pathology 200 Core Course for Medical Students, Department of Pathology, Basic Principles of Pathology, lecture on "Mechanisms of Environmental Lung Injury."
Honors & Publications
Academic and Professional Affiliations
- Member, American Heart Association Mid-Atlantic Consortium Study Section, Baltimore, MD
- Ad Hoc Reviewer, National Heart Lung and Blood Institute (NHLBI) Acute Lung Injury SCCOR Study Section, Bethesda, MD
- Ad Hoc Reviewer, University of California Tobacco-Related Disease Research Program Study Section, San Francisco, CA
- Ad Hoc Reviewer and Committee Member, Berrylium Rule Advisory Committee. U.S. Depart. of Energy
- Committee member, North Carolina Visiting Pulmonary Scholar Program, co-hosted by Duke University, University of North Carolina, North Carolina State University, Glaxo-Welcome, US EPA and CIIT Centers for Health Research
- Coordinator, North Carolina Visiting Pulmonary Scholar Program
- Member, American Thoracic Society
- Sigma Xi Honorary Member
- Board Member, Environmental Federation of North Carolina
- Editor, Experimental Lung Research
- NIH Postdoctoral Fellow, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
Ad Hoc Reviewer for Journals
- Journal of Biological Chemistry
- Journal of Clinical Investigation
- Journal of Experimental Medicine
- Journal of Immunology
- American Journal of Respiratory Cell and Molecular Biology
- American Journal of Physiology: Lung Cell and Molecular Physiology
- American Journal of Pathology
- Free Radical Biology & Medicine
- Completed publications in Scientific Journals - 52
- Manuscripts submitted or in preparation - 4
- Book chapters and review articles - 20
- Ph.D. Animal Physiology, Mississippi State University, Starkville, MS
- M.S. Biology, Middle Tennessee State University, Murfreesboro, TN
- B.S. Biology, Middle Tennessee State University, Murfreesboro, TN