- Synthetic and discovery organic chemistry for the pharmaceutical industries with applications in CNS, cancer, and pain.
- Preclinical development chemistry for pharmaceutical scale-up, metabolites, impurities, and deuterated drug candidates.
- Synthetic organic chemistry for in-vitro and in vivo diagnostics, including antigens and biotin conjugates with varied regiochemistry, macrocyclic ligands, nucleotide analogs, polycyclic heterocycles.
- Grant writing for drug discovery and medicinal chemistry from government, private non-profit and private for-profit sources.
- Design of patentable alternatives to existing molecules (drug candidates and in vitro diagnostic reagents).
- Design of patentable alternatives to existing synthetic procedures for drug candidates and nutritional supplements.
- Design and synthesis of synthons and fragments with rare substructures to facilitate discovery chemistry.
Undisclosed Company, Founder, President, and CEO, 2004 - Present
- Designed patentable alternatives to expensive fluorescent probes and managed a 14 step synthetic method. Multiple redesigns were required to reach the goal in this very challenging project.
- Developed 4 synthetic methods for small molecule linker conjugates (total of 15 steps) for antibody production and synthesis that are currently being used in late stage development and manufacturing of an in vitro diagnostic.
- Determined the structure of an unusual drug metabolite through synthesis of deuterated drug analogs for in vitro metabolic studies to better understand the mechanism of drug metabolism interpretation of LCMS, chemical derivatization, data and synthesis of plausible candidates for the metabolite.
- Optimized the purity in scale-up synthesis of a small molecule for pain treatment candidate which has shown highly significant activity in one clinical trial and has been awarded fast track designation in a second. Completed and developed synthetic methods for drug impurities to support stability studies for this candidate.
- Overcame severe solubility and purification issues to perfect the synthesis of an antigen-linker suitable for research, development and manufacturing. This in vitro diagnostic product was launched in 2017.
Cengent Therapeutics, San Diego, CA, Head of Combinatorial Chemistry, 1998 - 2005
- Established combinatorial chemistry and single molecule synthetic chemistry program.
- Targets: IKK, PTP1B, Anthrax Lethal Factor, and TNF.
Galderma Research, Inc., La Jolla, CA, Chemistry Coordinator, 1995 - 1998
- Dermatological drug discovery, including retinoids and other nuclear receptor ligands.
- Establishment of combinatorial chemistry and chemoinformatics programs. (Joint appointment with Sidney Kimmel Cancer Center).
Sidney Kimmel Cancer Center, Associate Faculty Member, San Diego, CA, 1994 - 1996
- Development of oligoanionic antitumor and antiretroviral agents.
AntiCancer, Inc., Director of Chemistry, San Diego, CA, 1994
- Research primarily focused on development of strategies to decrease immunogenicity of a therapeutic enzyme, and development of strategies for liposomal drug delivery.
Research Institute of Scripps Clinic, La Jolla, CA, 1985 - 1994
Associate Member, Department of Molecular Biology
- Research objectives: rational chemotherapeutic drug design, self-assembling drugs target-selective synergism. Emphasis on drug biodistribution and synergism.
Honors & Publications
- NIH graduate fellowship.
Academic and Professional Affiliations
- American Chemical Society
- SBIR Phase I and II; 'Non-peptide Inhibitors-Anthrax Lethal Factor'
- NIH, 'Self-Assembling Antiretroviral Agents,' preclinical development, suramin analogs for the treatment of AIDS.
- AmFAR;'Bipartite HIV Protease Inhibitors'
- Shannon Award (NIH); 'Self-Assembly-Antiretroviral Agents'
- NIH 'Antitumor Specificity Amplification'
Publications and Patents
- Author and Co-Author of over a twenty publications
- Inventor-Co-Inventor of over a dozen patents
- Ph.D. Bioorganic Chemistry, Columbia University, New York, NY
- M.S. Organic Chemistry, Columbia University, New York, NY
- B.A. Chemistry, (Summa cum Laude), Princeton University, Princeton, NJ