Drug Discovery and Development Expert, Including Chemistry Outsourcing Programs

Technical Consultant #1991


Expertise

  • Medicinal chemistry consulting and discovery.
  • Drug research and development (pre-clinical and clinical).
  • Patent interference consulting and IP management strategy.
  • Managing medicinal and organic chemistry outsourcing projects.
  • Licensing negotiations; due diligence.
  • Chemical safety training.
  • Neuroscience drug discovery.
  • Cardiovascular drug discovery.
  • Anti-infective drug research.
  • Syntheses of complex, diverse targets through novel methodologies.
  • Structure-based design using enzyme-inhibitor crystal structures.
  • Global organization in leading outsourcing and multi-disciplinary discover project teams.
  • Ligand-based drug design for G-protein-coupled receptors.

Expert Witness Experience

  • Provided expert testimony through depositions in patent interference and trade secret cases.

Experience

Independent Consultant, Present

  • Assignments include early phase research proposals of faculty or start-up entrepreneurs (e.g. QED program, University City Sciences Center).
  • Advise clients on drug design, research and development.
  • Guide clients on IP management strategy.

Bristol Myers Squibb, Hopewell, NJ, Senior Principal Scientist, 1987 - 2012

  • Led two projects for several years as a chemistry working group co-chair. Set strategy and co-managed the discovery research efforts of an interdisciplinary team of scientists, which placed compounds into safety assessment studies and clinical trials.
  • Delivered six development compounds, three Phase 1 compounds and one Phase 2b compound. Contributed to clinical development plans.
  • Directed the research of chemistry collaborators from external alliances in India and America which accelerated neuroscience and cardiovascular programs through the timely delivery of intermediates and final compounds.
  • Invented clinical candidates and promoted original research for schizophrenia, anxiety, depression, thrombosis and bacterial infections.
  • Solved complex problems in structure-based design, lead optimization, reduction in off-target activities and optimization of pharmacokinetic properties to rapidly identify candidate compounds.
  • Advised management on licensing opportunities and complex patent interference cases.
  • Designed efficient syntheses of complex targets from diverse chemical series (e.g. heterocycles, carbohydrates, macrocycles, peptidomimetics).
  • Wrote technical portions of external and internal regulatory documents.
  • Mentored junior scientists (B.S, M.S, Ph.D.) and cooperative education students.
  • Trained chemists in laboratory safety and organic chemistry.
  • Analyzed crystal structure data for enzyme-inhibitor complexes to discover structurally-diverse Factor XIa or Factor VIIa inhibitors which had high potency and/or oral bioavailability.
  • Designed efficient syntheses of complex macrocyclic inhibitors of Factor XIa and Factor VIIa.
  • Discovered gamma-secretase inhibitors for the possible treatment of Alzheimer's disease which had high potency, good oral bioavailability in rats and dogs and good brain penetrance in rats.
  • Invented Corticotropin-Releasing Factor (CRF) receptor antagonists for the possible treatment of depression or anxiety disorders.
  • BMS-562086, a CRF antagonist was safe in Phase I and Phase IIa clinical trials and was entered into proof-of-concept Phase IIb clinical trials for anxiety and depression.
  • Discovered sigma protein ligands for the potential treatment for schizophrenia including the clinical and backup candidates for the program.

Pfizer Inc., Groton, CT, Senior Research Scientist, 1981 - 1987

  • Designed potent antibacterial and anticoccidial drugs for the treatment of drug-resistant infections.

Honors & Publications

Credentials

  • Patent agent training.

Languages

  • German (reading and writing)

Academic and Professional Affiliations

  • American Chemical Society, Medicinal and Organic Chemistry Divisions
  • Pharmaceutical Consulting Consortium International, Inc.
  • ChemPharma Professional Association

Publications and Patents

  • Author on 43 articles in peer-reviewed journals.
  • Author on 41 presentations before national and international scientific meetings.
  • Inventor on 29 published U.S. Patents and on 18 published foreign patents.

Education

  • Ph.D. Chemistry, Yale University, New Haven, CT
  • M.S. Chemistry, Yale University, New Haven, CT
  • B.S. Chemistry, Yale University, New Haven, CT
Save Resume #1991
to Contact Form?

You must first click "Yes" to save this resume

Submit Request

You have no Saved Resumes

Add resumes within our various Ares of Expertise by clicking "Add Resume(s)" below.

Add Resume(s)