Molecular Biologist Expert in Clinical Diagnostic Research and Development, CLIA Compliance, DNA Repair and Oncology

Technical Consultant #1952


Expertise

  • Clinical diagnostic research and development, oncology, gene therapy and editing, translational medicine, and industrial microbiology.
  • DNA repair, gene therapy, gene repair and editing.
  • Oncology research, including small molecule aptamers and translational medicine.
  • Industrial microbiology and synthetic biology strain engineering to improve peptide production in E. coli.
  • CLIA accreditation and compliance for clinical diagnostic laboratories.
  • Collaboration with physicians and researchers to explore and market new diagnostic opportunities.
  • Management experience with research and laboratory operations.
  • Next generation sequencing (NGS) technology experience for genome, exome, RNA-sequencing.
  • Clinical diagnostic assay research for Borrelia burgdorferi, Lyme disease.
  • Expert Panelist with the Rare Genomics Institute, which helps patients with orphan diseases initiate and fund personalized research projects through a dedicated microfunding platform and highly-selective network of leading academic scientists and commercial institutions.

Experience

Undisclosed Company, Chief Operating Officer, 2012 - Present

  • Next generation sequencing (NGS) technology for genome, exome, RNA, and a variety of clinical disease panels.
  • Development of commercialization of large-scale genetic diagnostic information in a disease-specific manner (e.g., deafness-causing, cancer-related, for both research and clinical purposes.

Rare Genomics Institute, St. Louis, MO, Expert Panelist, 2012 - Present

  • Assist patients with orphan diseases initiate and fund personalized research projects through a dedicated microfunding platform and highly-selective network of leading academic scientists and commercial institutions.

Advanced Laboratory Services, Sharon Hill, PA, Associate Director, 2011 - 2012

  • Participate in the daily operations of a medium to high complexity clinical diagnostic laboratory.
  • Developing new-to-market diagnostics while providing high quality services for our clients and their patients.
  • Contribute to research, development, sample processing, marketing, and management of 12-member clinical and research team.

E.I. DuPont de Nemours & Co., Wilmington, DE, Molecular Biologist, 2008 - 2011

  • Central Research & Development (CRD).
  • Biochemical Science and Engineering (BCSE).
  • Strain engineering to improve peptide production in E. coli strains.
  • Identify traits beneficial for project goals in fermentation.

University of Delaware, Newark, DE, Doctoral Candidate, 2002 - 2008

  • Targeted gene repair in mammalian cells using single-stranded DNA oligonucleotides in an applied genomic laboratory.
  • Novel use of single-stranded DNA oligonucleotides to selectively kill tumor cells.
  • Research Assistantship: Delaware Center for Translational Cancer Research.

Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, 2000 - 2002

  • Senior Laboratory Technician, Molecular Microbiology and Immunology Laboratory
  • Studied the genetic diversity of Borrelia burgdorferi, and abiotic and biotic factors effecting the life cycle of Borrelia.

Honors & Publications

Academic and Professional Affiliations

  • American Association of Cancer Research (AACR)
  • American Society of Human Genetics (ASHG)

Awards

  • Gettysburg College, Deans Honor List and Deans Commendation List

Publications and Patents

Author and Co-Author of numerous publications in peer reviewed journals - subject matters:

  • Polypeptide self-assembly enhances its expression, processing, and function in a Bionanotechnology application.
  • Using bleomycin to stimulate targeted gene repair activity in mammalian cells.
  • A specific guanosine-rich oligonucleotide, capable of forming stable quadruplex structures selectively blocks proliferation and induces apoptosis in esophageal tumor cells.
  • Single-strand DNA Oligonucleotides increase sensitivity of cancer cells to chemotherapeutic agents.
  • Mammal Diversity and Infection Prevalence in the Maintenance of Enzootic Lyme Disease.
  • Spotted-fever group Rickettsia in Dermacentor variabilis.
  • DNA damage and homologous recombination regulate the frequency and process of targeted gene repair.
  • Abiotic and biotic factors affecting the enzootic cycle of Lyme disease.
  • Environmental factors contributing to the prevalence of Lyme disease in the white-footed mouse populations.
  • 2 U.S. Patents.

Education

  • Ph.D. Biology, University of Delaware, Newark, DE
  • B.S. Biology, Gettysburg College, Gettysburg, PA
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