Pharmaceutical Consultant for Oncology Drug Discovery and Development

Technical Consultant #1639


Expertise

  • Pharmaceutical / biomedical research scientist with 34 years of experience in the area of oncology.
  • Drug discovery research in the Cancer Department at Merck Research Labs.
  • Demonstrated track record identifying protein targets involved in the cancer disease process and developing small molecules that inhibit their functional activity.
  • Evaluate and integrate outcomes data from a variety of sources.
  • Recognized as an excellent mentor and motivator of research staff and colleagues, capable of maintaining a high level of productivity and achieve program objectives.
  • Developmental biology.
  • Cellular biology.
  • Molecular biology.
  • Animal model systems (oncology).
  • Cell cycle regulation - signal transduction.
  • Apoptosis/survival signaling.
  • Cancer target ID and validation.
  • Assay and drug development (oncology).

Experience

Independent Consultant, 2009 - present

  • Target ID /validation /drug discovery and development, with clients, including Locus Pharmaceuticals and GlaxoSmithkline.

GlaxoSmithkline Research Laboratories, Collegeville, PA , Manager, 2007 - 2008

  • Oncology target ID and validation cell based assay development (myc, ALK, EGFR family).

Merck Research Laboratories, West Point, PA,1982 - 2007

Senior Investigator,1999 - 2007

  • AKT program (led to development of MK2206).
  • IGFR program.
  • PSA-conjugate program.

Senior Research Fellow, 1995 - 1999

  • HPV E7 oncology program.
  • Apoptosis targets (caspases, Bcl2 family members).
  • Rb interacting proteins.

Research Fellow, 1990 - 1995

  • Growth factors and their receptors (TGFa, HER family members).
  • Transcription factor signaling.
  • Ras proteins for cellular signal transduction.

National Institutes of Health, Bethesda, MD, Research Associate, Laboratory of Molecular Oncology, 1978 - 1982

  • Identification, cloning and expression of Ras family proteins.

Columbia University, New York, NY, Research Assistant, Department of Cancer Research, 1974 - 1978

  • Development of two step carcinogenesis models.
  • Tumor promotion by phorbol esters.

Honors & Publications

Academic and Professional Affiliations

  • American Association for the Advancement of Science
  • American Association for Cancer Research

Training

  • Developmental Biology
  • Cellular Biology
  • Molecular Biology
  • Animal Model Systems
  • Cell Cycle Regulation - Signal Transduction
  • Apoptosis/Survival Signaling
  • Cancer Target ID / Validation / Drug Development

Publications and Patents

  • 58 publications
  • 7 patents

Education

  • M.S. Molecular Biology, American University, Washington, DC
  • B.S. Biology, SUNY at Geneseo, NY
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