Medicinal Chemist Consultant: Atherosclerosis, Allergy Respiratory and Inflammation Therapies

Technical Consultant #1423


Expertise

  • Experienced medicinal chemist. Delivered 17 active pharmaceutical compounds into development with the most advanced currently in Phase 2 trials.
  • Served 6 years on clinical development teams and co - chaired the HIV protease development team.
  • Sustained record of delivering quality API clinical candidates for atherosclerosis, infectious disease, allergy respiratory, inflammation, and cardiovascular therapies.
  • 8 years of pharmaceutical discovery management, including utilizing external chemists, restructuring portfolios, and mentoring 50 chemistry colleagues.
  • Experienced with most pharmaceutical target types including: Enzymes, proteases, kinases, GPCRs, nuclear hormone receptors, ion channels and projects of unknown mechanism.
  • Developed and implemented a chemistry department performance management philosophy and career development process as a member of the chemistry executive leadership team.
  • Licensing team contributor for 8 years performing due diligence on drug candidates.

Experience

Pfizer Pharmaceuticals, Groton, CT and Ann Arbor, MI, 1999 - 2007

Senior Director Cardiovascular/Atherosclerosis Chemistry, Ann Arbor, MI

  • Led a group of 35 - 50 chemists working on FXa, HMGCoA reducase, PPARs, renin, and other targets delivering multiple clinical candidates per year.
  • Chair of the CV Athero discovery team responsible for therapeutic area deliverables, scientific diligence, project entry and termination, cross discipline alignment and portfolio progression.
  • Implemented exploratory chemistry meetings that enhanced the scientific rigor of chemical matter triage, reduced project time lines and improved alignment with partner lines.

Inflammation Chemistry: Parallel Synthesis Lab, Groton, CT

  • Managed a group of approximately 30 (11 Ph.D.) chemists working on P2X7, P38, MMP13, Glucocorticoid Receptor Modulators, and other targets that delivered a clinical candidate per year.
  • Improved the zone parallel synthesis lab impact by ensuring full integration into project teams.
  • Stopped a compound from entering development due to unnecessary safety risks.

Manager Allergy and Respiratory Chemistry, Groton, CT

  • Managed a group of 18 (6 Ph.D.) chemists working on PDE - 4, VLA4, CCR - 3, and other targets that delivered a clinical candidate per year.
  • Implemented exploratory chemistry meetings enhancing chemical matter diligence, improving biology, chemistry, drug metabolism alignment, and ensuring a sustained portfolio.

Parke - Davis Pharmaceuticals, Ann Arbor, MI, 1989 - 1999

  • Coordinator of Antiviral chemistry: Worked with the Infectious Disease management team to prioritize projects targeting HIV, HSV, and CMV.
  • Coordinated 11 chemists (3 Ph.D.) working on targets including Fab - I, Non - peptide HIV - protease, HIV - integrase and others.
  • Coordinator of the HIV - protease project.
  • Built a highly functional anti viral chemical team that went from mass screen hits to nominating several development compounds.
  • Atherosclerosis chemical coordinator of the 15 - lipoxygenase project
  • Worked on CNS-CCKB antagonists and radical scavengers for Atherosclerosis.

Schering - Plough Pharmaceuticals, Kenilworth, NJ, 1987 - 1989

  • Experience with atherosclerosis (ACAT inhibitors) and CNS (dopamine D - 1 antagonists).

Honors & Publications

  • American Chemical Society; Organic and Medicinal Chemistry Divisions; IUPAC; Sigma Xi, AAAS
  • 22 publications and co-publications. Details available upon request.
  • 20 patents. Details available upon request.

Education

  • Post - Doc., Yale University, New Haven, CT
  • Ph.D., Organic Chemistry, Wayne State University, Detroit, MI
  • B.S., Chemistry, ACS Certified Degree, Andrews University, Berrien Springs, MI
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