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Drug Discovery and Pharmaceutical Chemical Development Expert

Technical Consultant #1968


Expertise

  • A Medicinal Chemist with an extensive and diversified background in drug discovery.
  • Discovery of a smallpox inhibitor utilized in major biodefense agencies.
  • Computer aided drug design and creative applications of organic chemistry.
  • Implements and manages database solutions and robotic applications.

Key Competencies

  • CMC and IND support.
  • Drug discovery.
  • Chemical development.
  • Establishing and managing robotic solutions.
  • Managing complex scientific instruments.
  • Team leadership and coordination, building effective project teams.
  • Implementing and managing database solutions.
  • NMR (Nuclear Magnetic Resonance), FT-IR (Fourier Transform Infrared Spectroscopy), GC/MS (Gas Chromatography - Mass Spectrometry), LC/MS (Liquid chromatography - Mass Spectrometry), HPLD, (High-Performance Liquid Chromatography).
  • Using organic chemistry to solve synthetic problems.
  • Molecularly targeted approach.
  • Establishing and managing robotic applications.
  • Computer-assisted drug design.

Experience

Undisclosed Company, Medicinal Chemist Consultant (Owner), 2011 - Present

  • Oversees early drug discovery and source manufacture of API and write chemistry CMC's.
  • Establish infrastructure and screening libraries for start-up businesses provide preclinical support.
  • Evaluate SAR and support sale of specific intellectual property for ViroPharma.
  • Manage manufacturing of clinical candidate API, provide virtual chemical development, and support IP legal.
  • Serve on Scientific Board of Advisors for Combs Laboratories LLC.

Cephalon, Inc., West Chester, PA, 2004 - 2011

Senior Scientist II - Chemistry Administration, 2009 - 2011

  • Responsible for Chemistry Administration.
  • Identified and implemented Dotmatics and ChemInventory, key departmental software tools.
  • Oversaw group and responsible for supporting chemistry activities such as registration, and storing proprietary compounds, dispensing chemical procurement and inventory, equipment and supplies.
  • Supported the management of SAI Advantium an outsourced chemistry collaboration.
  • Proposed and executed scaffolds that provided novel IP for existing products.
  • Expertly managed automation including bringing robotics on line and on time.

Senior Scientist II CNS, 2004 - 2009

  • Oversaw CNS lead optimization that directed target selection.
  • Led three scientists performing CNS candidate selection.
  • Member of successful H3 project team delivering potent inverse agonist clinical candidate.
  • Led group that delivered proof of concept for the 5-HT6 receptor antagonist project.
  • Calculated target drug-like properties for CNS projects.

Viropharma, Exton, PA, 1995 - 2004

Fellow, Principal Scientist and Senior Scientist - Department of Medicinal Chemistry

  • Managed seven chemists, three Ph.D.s and four associates and oversaw orthopox inhibitor program.
  • Invented a smallpox drug which was selected by U.S. government resulting in a bid of $433 million.
  • Headed "hit-to-lead" in discovery, identifying investigation hits in viral projects and moving toward decision.
  • Identified all Hepatitis C leads being pursued with three entering clinics with VP-796 (HCV pol) demonstrating proof of concept in Phase II.
  • Identified new lead series in HCV pol, orthopox and viral hemorrhagic fever.
  • Led group that identified and directed synthesis of first hepatitis C polymerase inhibitor that advanced to Phase II clinical trials.
  • Managed Hepatitis C alliance with Wyeth-Ayerst as coordinating chemistry between the two groups.
  • Advanced compounds to lead status through the coordination of biology, chemistry, DMPK, analytic and outside parties.
  • Supported drug discovery through selection of ActivityBase for corporate database and ACD's chemical property prediction software.
  • Acquired over 300,000 new chemical entities.
  • Recruited and hired chemists and established departmental budget as acting director.

Sterling Winthrop, Inc. - Sanofi Winthrop, Inc., NY and PA, 1985 - 1995

  • Filling the rolls: Principal Research Investigator, Senior Research Investigator, Senior Research Chemist for the Department of Medicinal Chemistry.
  • Designed potent inhibitor, which led to NDA candidate Pleconaril and identified back-ups by identifying bioisosteres to isoxazole functionality using x-ray crystallography and computer-assisted design.
  • Identified promising hits as project chemist for Herpes and HIV Tat and Rev programs , and selected compounds for screening, planned synthetic approaches to targeted mechanisms, synthesized where appropriate, interpreted SAR, and presented findings.
  • Developed convenient palladium catalyzed method for generating heterobiaryls which was widely cited after publication and found widespread use in several Sterling projects.
  • Responsible for bar coding and managerial oversight of chemical inventory.

Honors & Publications


Credentials

  • Postdoctoral Fellow, Colorado State University, Ft. Collins, CO

Academic and Professional Affiliations

  • American Chemical Society: Medical Chemical Division and Organic Division
  • New York Academy of Sciences

Publications and Patents

  • Author and Co-Author of numerous publications and lectures
  • 5 U.S. patents.

Education

  • Ph.D. Organic Chemistry, Pennsylvania State University, State College, PA
  • B.S. Chemistry, Ohio State University, Columbus, OH
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