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Protein Drug Products Expert including Enzymes, Antibodies and Antigens

Technical Consultant #1823


Expertise

  • Purification and characterization of proteins and glycoproteins.
  • Protein and glycoprotein drug products including enzymes, antibodies and antigens.
  • Enzymology - development of reliable, linear assays (colorimetric, fluorometric, radioactive), kinetic analysis of enzymatic reactions.
  • Technical writing and editing (e.g., CMC sections of new drug applications, biological licensing agreements; technical reports, white papers, development reports, validation reports).
  • Miscellaneous separation techniques (e.g., dialysis, ultrafiltration, membrane centrifugation lyophilization).
  • Immunochemical techniques (e.g., ELISAs, RIAs, blotting analysis, immunoprecipitation, double immunodiffusion).
  • Chromatographic techniques (e.g., column, HPLC, GLC, HP-TLC).
  • Electrophoretic techniques (e.g., SDS-PAGE, Native-PAGE, capillary electrophoresis, isoelectric focusing, pulsed field gel electrophoresis).
  • Centrifugal techniques (e.g., differential, velocity sedimentation, velocity density, Isopycnic).

Experience

Undisclosed Company, President, 2010 - Present

  • Protein therapeutics.

Lehigh University, Bethlehem, Pennsylvania, 1982 - Present

  • Professor of Chemistry Emeritus, 2010 - Present
  • Professor, Chemistry Department, 1995 - 2009
  • Professor, Chemistry Department, Head, Biochemical Sciences, and Director, Institute for Health

Sciences, 1989 - 1995

  • Professor, Chemistry Department and Head, Division of Biochemical Sciences, 1984 - 1989
  • Professor, Chemistry Department, 1982 - 1984

University of California at San Diego, School of Medicine, La Jolla, CA, 1972 - 1982

  • Associate Professor, Neurosciences Department, 1981 - 1982
  • Assistant Professor, Neurosciences Department. 1975 - 1981
  • Assistant Research Neuroscientist, Neurosciences Department, 1974 - 1975

N.I.H. Postdoctoral Fellow, Department of Neurosciences, 1972 - 1974

Research Projects

  • Digestive Care Inc., Characterization of Pancrelipase Proteins.
  • LESN Research Fund: Sperm Fucosidase Study.
  • Biochemical Basis of Human Disease Fund.
  • St. Lukes Hospital: Breast Cancer/Cathepsin D Study and STC Diagnostics,Cathepsin D in node-negative breast cancer patients.
  • Minister of Science and Education (Spain), purification and characterization of rat sperm.
  • Pool Health Care Trust: Neurotoxicity of human tissue ribonuclease II N, human tissue ribonuclease isoenzyme glycosylation, surgical oncology and, characterization, identification of a compound enriched in Cystic Fibrosis urine and biochemical markers in cancer patients.
  • Merck & Co., Inc., Glycosylation of monoclonal antibody and glycosylation of recombinant hepatitis B surface antigen.
  • National Institutes of Health: Studies on the carbohydrate moieties of ą, A Preparative Ultracentrifuge, and human liver ą-L-Fucosidase and Fucosidosis, and human liver sialytransferase and ą-L-Fucosidase.
  • Cystic Fibrosis Foundation: Studies on cystic fibrosis tissue ą-D-Glucosidase.
  • Kroc Foundation: Characterization of altered glycoprotein metabolism in human diabetes.
  • American Lung Association: Cystic fibrosis - biochemical studies and studies on the biochemical defect in cystic fibrosis.
  • National Foundation - March of Dimes: Fucosidosis, human ą-L-Fucosidase and Mental Retardation.

Honors & Publications


Academic and Professional Affiliations

  • Biochemical Society
  • American Association for Advancement of Science

Awards

  • Honors Graduate, University of Chicago
  • NIH Postdoctoral Fellowship
  • NIH Research Career Development Award
  • Briody Award for Teaching and Advising
  • Case National Professor of the Year Nominee
  • National Institutes of Health: Research Career Development Award

Publications

  • Approximately 100 Scientific Publications and 10 Invited Reviews, Chapters of Books, and Monographs.
  • 75 Papers Presented at Scientific Meetings and Universities

Education

  • Ph.D. Biochemistry, University of Oregon Medical School, Portland, OR
  • B.A. Psychology, University of Chicago, Chicago, IL
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