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Drug Development and Drug Delivery Consultant

Technical Consultant #1406


Expertise

  • Functional properties of IgA.
  • Development of oral vaccine delivery technologies.
  • Effectiveness of host-parasite relationships.
  • Mechanisms of adherence and pathogenisis.
  • Transport of macromolecules across the intestinal epithelium.
  • Receptor mediated endocytosis.
  • Isolation, purification and refolding of proteins produced by recombinant DNA technology, including disulfide formation.
  • Covalent conjugation of peptides and proteins to carriers for oral delivery and to immunostimulatory molecules for parenteral delivery.
  • Studies on mechanisms of controlled release of bioactive molecules from microspheres and other polymer systems.
  • Development of oral drug delivery systems.
  • Development of biodegradable nanoparticles.
  • Development of targeted delivery systems.
  • AsialoGlycoProtein receptor.
  • Development of tumor targeting agents.
  • Development of transdermal drug delivery systems.
  • Development of oral nanolattices for protein drugs.

Experience

Undisclosed, Science Director, Australia, 2005 - 2007

  • Road show presentations of transdermal and oral technologies to corporate and individual investors.
  • Identification of potential business opportunities for in-house ransdermal and oral technology, including market research and identification and assessment of competitive technologies.
  • Development of transdermal drug delivery systems for insulin, IGF1, GHRP-6, THC, AdeCbl (NO scavenger), EGF.
  • Development of topical anti-inflammatory molecules.
  • Development of novel nanolattice systems for oral delivery of proteins (insulin, anti-TNF molecules).
  • Investigation of the ability of riboflavin to act as a targeting agent for oral delivery.
  • Investigation of alternative UVA and UVB sunscreen agents.
  • Development of a topical melanoma vaccine.
  • Planning, set-up and establishment of animal house and staff training.

Access Pharmaceuticals, Australia, Director/Vice President 2002 - 2005

  • Investigation into the ability of folate, biotin and vitamin B12 to target imaging agents and cytotoxics (Platinum, Daunomycin, Methotrexate, Gallium) to tumor cells.
  • Development of targeted delivery system for Inflammatory conditions.
  • Management of research team, generation, preparation and maintenance of IP.
  • Planning, set-up and establishment of the Access AEC, animal house, training of animal house staff.

Biotech Australia Pty. Ltd., 1983 - 2001

Manager, Targeted Delivery Group, 2001

  • Development of oral delivery systems for peptides, proteins, hormones, drugs enveloped in nanoparticles.
  • Development of vitamin-mediated targeting system for cancer treatment.
  • Investigation into the ability of folate, biotin and vitamin B12 to target imaging agents and cytotoxics to tumor cells.
  • Development of an alternative to PEG.
  • Development of an oral form of GHRP.
  • Development of an immunological desensitizing agent.

Project Manager/Skill Group Manager Immunochemistry, 1999

  • Development of oral delivery systems for peptides, proteins, hormones, drugs enveloped in nanoparticles.
  • Development of an immunocastration vaccine for dogs and cats.
  • Development of oral vaccine technology.
  • Management of research team, generation, preparation and maintenance of IP.

Senior Principal Research Scientist, 1993

  • Development of oral delivery systems for G-CSF and EPO (collaboration with Amgen, 1000 Oaks).
  • Development of an oral delivery system for gamma Interferon (collaboration with Roche, Basel)
  • Development of an oral delivery system for Insulin (collaboration with Hoechst, Frankfurt).
  • Development of controlled release formulations for vaccines.
  • Management of research team, generation, preparation and maintenance of IP.

Principal Research Scientist, 1989

  • Development of oral delivery systems for peptides, hormones and drugs.
  • Development of an immunological castration system for dogs and cats.
  • Management of research team, generation, preparation and maintenance of IP. Presentation of reports, maintenance of International Collaborations.

Honors & Publications


  • Forty six publications.
  • Fifty three presentations.
  • Forty seven patents, granted or applied.

Education

  • Ph.D., Microbiology and Immunology, Adelaide University
  • B.S., Microbiology and Immunology, Adelaide University
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