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Molecular Virologist

Technical Consultant #1072


Expertise

  • Mammalian biology
  • Molecular cell biology
  • Virology, microbiology
  • Molecular genetics
  • Drug discovery and development
  • Computational biology and informatics

Experience

2001 - 2003 Physiome Science, Princeton, NJ

Director of Software Product Planning and Biological Sciences

  • Computational biology and informatics
  • Advanced computer simulation of complex biological systems, pathways, and networks for drug discovery .
  • Development of biological simulation software and predictive biomodels.
  • Scientific concept mining systems define new technology for defined problems.
  • Developed business relationships with biotechnology and pharmaceuticals clients

2001 University of Delaware Biology Department, and NSF

  • Designed and promoted a campus-wide technology infrastructure plan.
  • Led and facilitated the Biology Department business retreat.
  • Reviewed NSF national center proposal.

2000 - 2001 Management Team Establishing the Delaware Biotechnology Institute, Newark, DE, Assistant to the Director

  • Created budget and technical facility financial plan.
  • Led Scientific Advisory Board as management team representative. Led the management team strategic planning sessions.
  • Wrote strategies for, and sections of, successful federal center granted applications (NIH, NSF).

1990 - 1994 DuPont Merck Pharmaceutical Co., Wilmington, DE

Director of Applied Biotechnology

Supervised two research groups that formed a 52-person organization:

  • Managed over 25 research projects in 5 therapeutic areas.
  • Created a sweeping new scientific program in integrin biology.
  • Produced many multi-gram quantities of purified proteins for screening and structural biology.
  • Guided post-doctoral scientist in the creation of oocyte and patch-clamp electrophysiological assays for rapid cloning of neural cGMP-coupled receptors and drug screening.
  • Invented a novel yeast-l-hybrid system that rapidly cloned genes corresponding to substrate-specific yet previously unknown proteases.
  • Demonstrated the validity and power of single-chain antibody systems for rapidly making discovery reagents.
  • Developed protein-family-specific SAGE systems that profiled gene expression complexity in human disease and the changes during drug treatment.
  • Created novel degenerate PCR systems used to clone gene families of drug targets; including suppression PCR normalization and targeted subtractions.
  • Invented a unique differential display system (DDGE) that identified gene family members whose expression changes during disease progression.
  • Created novel oligonucleotide-directed subtraction protocols (capture) for constructing gene-family-enriched libraries.

Honors & Publications


Invited Lectures

  • Recombinant DNA Methods in Biotechnology: Boston College and the Genetic and Toxicology Research Society of America.
  • Strategies for Cloning Gene Families, University of Pennsylvania, Medical and Graduate Schools.
  • The Company Representative's Role as Consultant in Promoting the Adoption of Advanced Technologies. Beckman Coulter Regional Sales Meeting, Lewes, DE.

Publications

  • 13 peer reviewed publications; 5 in-progress/under-revision; 17 additional articles published by Applied Molecular Biology and Biotechnology Resources reports during 1990-1994.

Education

  • Ph.D. University of Alabama, Birmingham, AL, Molecular Virology
  • M.S Western Illinois University, Macomb, IL, Cell Biology and Biochemistry
  • B.S. Western Illinois University, Macomb, IL, Zoology, Chemistry, Philosophy
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