Pharmaceutical Process Research Consultant: Synthesis and Process for API, Controlled Substances and Platinum Compounds (1487)
Expertise
- Synthetic organic chemistry for active pharmaceutical ingredients (API).
- Pharmaceutical process research, development and scale up.
- Organic synthesis, including platinum chemistry and synthesis of controlled substances such as cannabinoid, opiod and methamphetamine compounds.
- Skilled at terpene, heterocyclic, amino acid and organometallic chemistry and asymmetric synthesis.
- Good manufacturing practice (GMP) for pharmaceuticals.
- Development of anti tumor compounds.
Experience
Undisclosed Company, 1997 - 2008
Principal Scientist, 2008
Principal Scientist, 2008
- Conducted pharmaceutical process research and development, including GMP scale up of controlled substances and platinum compounds.
- Management and leadership duties of chemical process research and development.
- Project leader for tetrahydrocannibinol (THC), nabilone, dexanabinol, metaxalone, methamphetamine, methyl phenidate, and platinum anticancer drugs oxaliplatin, JM-216 (satraplatin), carboplatin, and cisplatin.
- Project leader for tetrahydrocannibinol (THC), nabilone, dexanabinol, metaxalone, methamphetamine, methyl phenidate, and platinum anticancer drugs oxaliplatin, JM-216 (satraplatin), carboplatin, and cisplatin.
- Invented novel syntheses of anti-emetic THC, and demonstrated novel terpene chemistry; successfully validated process in plant, leading to commercializaton.
- Researched, developed, and successfully scaled process for anti-emetic cannabinoid nabilone; successfully scaled process in GMP laboratory.
- Researched new synthetic route to cannabinoid drug candidate dexanabinol and demonstrated novel route to cannabinoids.
- Researched and successfully developed process for benzodiazepine anti-anxiety drug lorazepam.
- Rapidly discovered and developed new process for muscular relaxant metaxalone; process was validated in the plant and commercialized.
- Supported ongoing plant operations for carboplatin and cisplatin; improved the carboplatin recrystallization procedure in the plant.
- Successfully validated a difficult process for platinum anticancer drug candidate JM-216 (satraplatin).
- Did an extensive cost analysis of approaches to economical synthesis of D-methyl phenidate resulting in new syntheses of racemic and chiral methyl phenidate, drastically reducing cost and cycle versus earlier processes.
- Discovered and demonstrated new process for methamphetamine.
- Discovered and demonstrated new process for benzphetamine.
- Invented and developed a new, very simple process for purification of morphine from concentrated poppy straw (CPS), drastically reducing cost and cycle time from the earlier process. Process was validated in the plant and commercialized.
- Rapidly discovered and developed a new crystallization procedure for hydrocodone, and discovered new polymorph.
- Invented new synthesis of oxycodone from 14-hydroxycodeinone.
- Wrote, edited articles, consultant to other authors, and gave scientific advice.
- Conducted pharmaceutical process research.
- Invented, successfully developed and scaled new synthetic routes to the important anti tumor drugs etoposide phosphate and etoposide.
- Oversaw technology transfer to Swords, Ireland facility.
- Helped develop the process for the anti-coagulant ifetroban.
- Worked on processes for the amino acid derivative eflornithine and the ACE/NEP inhibitor omapatrilat.
Honors & Publications
Publications and Patents
- Ten publications - Publication list available up requests.
- Six patents
Education
- Ph.D. Organic Chemistry, University of Delaware, Newark, DE
- B.S., Chemistry, George Washington University, Washington, DC