Medicinal and Organic Chemistry Expert: Antibacterials and Antiparasitics

Technical Consultant #2050


Expertise

  • Medicinal and organic chemistry: program review, SAR analysis, new targets, direct programs at CROs.
  • Therapeutic areas: Antibacterials, antiparasitics, steroids, natural products, estrogen receptor, diabetes, obesity, thrombosis, and animal health.
  • Evaluation of drug discovery programs and potential products as part of investor due diligence.
  • Synthetic route design and troubleshooting.
  • Structure determination of unknown reaction products and novel compounds.
  • Radiolabeled pharmaceuticals - compound design and synthetic strategy.
  • Review of legal documents for scientific accuracy.
  • Evaluation of grant proposals.

Expert Witness Experience

  • Subject Matter Expert in organic chemistry, synthetic chemistry, and organic reaction mechanisms.
  • Patent coverage evaluation - identify potential gaps ("patent busting").

Experience

Undisclosed Company, Vice President and Chemistry Contractor, Present

  • Direct the chemistry aspects of the Company's research and development programs.
  • Provided drug discovery consulting services to the Company.

Undisclosed Company, Senior Consultant and Founder, Present

  • Served on review panels for NIH (National Institute of Health); reviewed SBIR (Small Business Innovation Research) /STTR (Small Business Technology Transfer) grant applications.
  • Served on review panels for DOD (Department of Defense) organized by SRA International (Society of Research Administrators); reviewed grant applications.
  • Evaluations of research programs and potential development compounds for a venture capital firms.
  • Served as drug discovery consultant and part time VP of Chemistry for RiboNova.

Merck & Co., Inc., Rahway, NJ, Principal Scientist, 1985 - 2013

Distinguished Senior Investigator, 2007
Senior Investigator, 1999
Associate Director, 1994
Research Fellow, 1989
Senior Research Chemist, 1985

  • Led the chemistry team that discovered MK-7655, a beta-lactamase inhibitor that is currently in Phase II clinical trials.
  • Served as chemistry representative on the Early Development Team (EDT) for MK-8712.
  • Led the chemistry group (10 chemists) that discovered two carbapenem antibiotic preclinical candidates for the treatment of MRSA infections. One, L-786,392, advanced to a Phase I multi-dose clinical trial.
  • Directed external groups (up to 25 chemists) on 4 programs at CROs (WuXi (China) and AMRI (Singapore).
  • Participated in outsourcing and licensing activities including visits to Shanghai, China and Gotembe, Japan.
  • Member of the Process Chemistry Scientific Advisory Committee (SAC), a team of senior chemists that served as internal consultants and reviewed synthetic routes for development compounds and suggested improvements that increased efficiency and reduced costs.
  • Member of the Late Stage Functionalization group, a team of experienced synthetic chemists that was formed to apply the latest synthetic methodology to complex drug molecules.
  • Member of the Stereochemical Assignment Task Force, a group of senior Merck scientists that was assigned to solve stereochemical problems.
  • Key contributor to the discovery of ER-alpha "super antagonists" active against Tamoxifen-resistant tumors and the discovery of a novel anti-hypertensive agent.
  • Discovered a series of promising next-generation avermectins for parasitic infections in dogs.
  • Developed an in vitro assay using brine shrimp as a useful surrogate for antiparasitic activity.
  • Worked with patent attorneys to ensure intellectual property protection; drafted the claim structure for some patents.
  • Developed method for isotopic labeling of paraherquamide, an anti-parasitic oxindole alkaloid.

Columbia University, New York, NY, Postdoctoral Research Scientist, 1984 -1985

  • Postdoctoral research in natural products chemistry and organic synthesis with Professor Koji Nakanishi.
  • Investigated the synthesis of steroidal marine natural products with shark repellent activity.
  • Prepared steroids, including a C-14 labeled steroid, for studies on cholesterol metabolism.
  • Isolated and purified brevetoxins from cultures brevetoxins from cultures of K. Brevis using established procedures.

Honors & Publications

Languages

  • Mandarin Chinese (beginner level)

Academic and Professional Affiliations

  • American Chemical Society - member, Organic and Medicinal Chemistry Divisions; served on two ACS award committees for 3 years each.
  • New York Academy of Sciences - member
  • Merck Polytechnic Institute courses: "Managing Across Cultures" and "Partnering Excellence"
  • Rutgers Center for Management Development - mini-MBA Biopharma Innovation (six-day program)
  • Partner Communications Course: "Executive Presentations Program"
  • Leadership Courses: "Innovate Like Edison" & "Creativity and Innovation Leadership"
  • Merck Research Laboratories Leadership Development Program

Awards

  • Postdoctoral Fellowship, National Institutes of Health
  • Graduate Fellowship, Whitaker Health Sciences Fund (M.I.T.)
  • Graduate Fellowship, National Science Foundation

Publications and Patents

  • Author and Co-Author of numerous publications in peer reviewed medical journals, science journals and other literature.
  • National meetings, lectures, and symposia
  • 19 U.S. patents

Education

  • Ph.D. Organic Chemistry, Massachusetts Institute Of Technology, Cambridge, MA
  • B.S. Chemistry, University Of Virginia, Charlottesville, VA
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