Gene Therapy, Virology and Proteomics Biomedical Sciences Consultant

Technical Consultant #2044


Expertise

  • Virology
  • Oncology
  • DNA repair and recombination
  • DNA replication
  • Protein-DNA interactions
  • Protein-protein interactions
  • Proteomics
  • Quantitative-Polymerase Chain Reaction, (PCR)
  • Allele specific-PCR
  • Antibody production-generation
  • Immunofluorescence
  • Immunobloting
  • Cell biology
  • Cancer biology
  • Molecular biology
  • Yeast genetics
  • Gene therapy
  • Recombinases
  • Site directed gene modifications.
  • Cloning, protein expression and protein purification.
  • Trained in various techniques routinely used in biochemistry.

Experience

Independent Consultant, Present

  • On call consultant - Global Advisor

Undisclosed University, Postdoctoral Associate, 2011 - Present

  • Designed a novel approach to identify proteins binding to abnormal DNA and RNA structures.
  • Initiated a collaboration with MIT and, identified proteins critical for gene therapy, genome stability and cancer.
  • Engineered a novel antibody-viral fusion protein to target radiation resistant cancer cells.
  • Designed and analyzed triplex forming oligonucleotides as tools for gene therapy, targeting genes involved in Hurler Syndrome, β-thalassemia and HIV infection; part of the work was incorporated in a successful SBIR grant proposal.
  • Current work led to a presentation at an international DNA-repair symposium and a manuscript.

University of Connecticut, Farmington, CT, Graduate Assistant, 2004 - 2010

  • Demonstrated an essential role of a viral nuclease in viral DNA replication and viral growth.
  • Identified 3 new interactions between viral and host proteins and these interactions are targeted for potential antivirals.
  • Invited student speaker at the International Herpes virus Workshop, Salt Lake City, Utah, 2010.
  • Peer reviewed scientific manuscripts for Journal of Virology, Virology and Journal of Biochemistry.
  • Thesis research led to one publication, 6 presentations at international conferences and, research was incorporated in a successful $200,000 Connecticut Stem Cell grant application.

Educator

  • Designed and taught laboratory classes for undergraduate students in biochemistry.
  • Designed, taught and supervised lab rotational projects for graduate students and research projects for undergraduate students.

Indian Institute of Science, Bangalore, India, Research Assistant, 2002 - 2003

  • Yeast two-hybrid system
  • Yeast genetics
  • Strain construction

Bharathiar University, Department of Biological Sciences, 1999

  • Leading a working committee of 6 students and one faculty for budgeting and appropriating the student association funds.
  • Organizing intra university science competitions.
  • Arranged student visits to biotech firms and research centers throughout India and, organized seminars from eminent scientists and entrepreneurs in life sciences.

Honors & Publications

Credentials

  • Postdoctoral Associate, Yale School of Medicine, New Haven, CT
  • Completed a course on 'Business of Biotech' organized by the Yale Health Care and Life Sciences Club.

Languages

  • English
  • Tamil
  • Hindi
  • Bengali

Academic and Professional Affiliations

  • New York Academy of Sciences
  • National Postdoctoral Association
  • Participant: Annual Yale Case competition

Awards

  • International graduate assistantship and tuition waiver awards, University of Connecticut Health Center
  • Keystone symposia education fund scholarship, Keystone symposia on DNA replication and recombination, Santa Fe, New Mexico

Publications and Patents

  • Co-Author: Herpes Simplex Virus Type 1 for the, Journal of Virology.

Invited Speaker

  • International Herpes virus workshop, Salt Lake City, UT
  • Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT
  • Molecular, Microbial and Structural Biology retreat, University of Connecticut Health Center, Hartford, CT

Poster Presentation

  • Keystone symposia on Genome Instability and DNA repair, Taos, NM
  • Keystone symposia on DNA Replication and Recombination, Santa Fe, NM
  • International Herpesvirus workshop, Seattle, WA
  • North Eastern Structure Symposia, Storrs, CT
  • Keystone symposia on Mechanisms of DNA Replication and Recombination, Keystone, CO

Education

  • Ph.D. Biomedical Sciences, University of Connecticut Health Center, Farmington, CT
  • M.S. Microbial Gene Technology, Madurai Kamaraj University, Madurai, India
  • B.S. Microbiology
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