Expert Medicinal Chemistry Consultant Specializing in Organic Medicinal Chemistry, and Patent Examination

Technical Consultant #1723


Expertise

  • Synthetic organic chemistry, analysis of various classes of compounds, achieving successful new challenges toward a position as a Medicinal Chemistry Consultant, and Consultant in chemical marketing.
  • Achieved and conceived synthetic methodology for construction of difficult glycosidic bonds unachievable by conventional synthetic methods, present in many natural compounds that display interesting biological activities as anti-cancer, anti-cardiac agents.
  • Large scale syntheses of monosaccharides.
  • Experienced in process chemistry, and clean GMP laboratories - medium large scale of diverse monosaccharides for preparation of large saccharides.
  • Parallel synthesis, for multi-step natural product synthesis, carbohydrate synthesis and glycoconjugates.
  • Natural product synthesis of cyclic compounds, C-C bond formation, and asymmetric synthesis of small molecules natural products.
  • Synthesis of, heterocyclic compounds, modified nucleotides and nucleosides.
  • Air sensitive compounds manipulating, including synthesis of various compounds, and organophosphorous compounds.
  • Organo-metallic elements transition, (Rhodium, Cobalt, and Palladium), and organosilicons for synthesis of various natural products.
  • Peptide synthesis, solid phase, peptidomimetics, and racimization analysis and purification by HPLC.
  • Experienced in 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY), other analytical techniques HPLC, GC-MS, IR-UV spectroscopy.

Experience

Undisclosed Company, Canada, Medicinal Chemistry Consultant, Present

  • Develop; devise new efficient synthetic schemes for anti-cancer, antiviral agents, such as small molecules, heterocycles, complex intermediates for natural peptidomimetics, asymmetric synthesis of bio-active compounds that are to be carried out in company's laboratory.

Undisclosed Company, Bellevue, WA, Scientific Consultant, Organic Chemistry, 2009 - Present

  • Writing solution report to support scientist to promoting discoveries and inventions that can lead to a patent allowance.
  • Participation in various laboratory sessions, meetings with industrial and federal scientists. Scientific reviewing of novel inventions in organic and nanochemistry.

Miami Dade College, Miami, FL, Adjunct Professor - General and Organic Chemistry, 2009

  • Lecture and laboratory teaching for first and second year college students, pre-nursing, pre-med, pre-pharmacy, biology and chemistry.

U.S. Patent and Trademark Office, Junior Scientific Patent Examiner, 2008

  • Junior patent examiner in Organic Chemistry, Biotech, Pharmaceutical.
  • Skills of patent examining applications, inventions, search of prior art by using multiple scientific and patent search software toward finding prior art.
  • Use of scientific specialty to determine prior art, patentability or non-patentability of organic chemistry inventions for chemical mixtures, natural products, polymers pertaining to Biotech-Pharma.

National Institute of Child Health and Human Development, Bethesda, MD, 2006 - 2008

  • As a Post-Doctoral Research Fellow research project focused on the synthesis and development of polysaccharides and lipido-aminoacids adjuvant and the combination of these adjuvants with a short saccharide or polysaccharide to construct a glyco-amino lipid derivative.
  • Synthesis of mono-saccharides in medium-large scale synthesis in clean GMP room laboratory, to construct oligosaccharides.
  • Linkage of glycoamino-lipids to a carrier protein in order to stimulate cellular immune defense.

Organic Chemistry Institute, University of Tubingen, Germany, Research Associate, 2001 - 2005

  • Developed and devised the total stereo and region-selective synthesis of cyclic disaccharides by Intra-molecular Glycosylation, an efficient methodology to create difficult glycoside linkages present in natural glycol-conjugates; unachievable by the conventional glycosylation method.
  • The cyclic products can be transformed into a polysaccharide to construct polysaccharide vaccines, glycoconjugates, dendrimers of medicinal importance.

Organic Chemistry Institute, University of Lausanne, Switzerland, Research Associate, 1993

  • Elaborated the design, chemical synthesis, and structure-function relationships of peptide-mimetics to mimic the turn conformation for potential use in drug development.
  • Purification of peptide mimetics by High Performance Liquid Chromatography (HPLC) and identification by diverse spectroscopic methods.

CIBA-Geigy, Agrochemical Division, Basel Switzerland, Synthetic Organic Chemist, 1992

  • Achieved the asymmetric synthesis of natural products by C-C bond formation, to be tested as pesticides, and fungicides for plant protection.
  • Completed the purification of these compounds by column chromatography and HPLC. Cooperation with biologists to study biological activity of these compounds on plants.
  • Wrote laboratory protocols to conform to the company's regulations, held seminars to interpret results, and attended seminars held by Ciba-Geigy's and other company's synthetic chemist.

Honors & Publications

Credentials

  • Graduated Magna Cum Laude (the highest credential awarded to a foreign - non-German, Ph.D. Candidate).
  • Numerous software search programs for patent examining, Patent Searching East, West, AOCS, and Dialog, also extremely helpful for bibliographical chemical searches pertaining to scientific research.
  • Tools: PowerPoint, MS-Word, Word Perfect, Excel, Windows 1998, 2000, 2003-2007.
  • Utilization of chemistry program softwares such as Chemsketch, Chemwindows, Chemdraw, STN, CAPLUS file registry, file registry chemical drawings (from STN) Beilstein, Sci-Finder, NMR-programs to retrieve and process 1 and 2 dimensional NMR spectrums.

Languages

  • Excellent communications skills, facility to integrate in multicultural, multi-ethnic groups, multidisciplinary groups and strong international experiences.
  • English
  • French
  • German
  • Spanish
  • Italian
  • Portuguese

Academic and Professional Affiliations

  • American Chemical Society
  • Member of the American Association for the Advancement of Science

Publications and Patents

  • Abstract and Ph.D. thesis work published.
  • 3 Articles published, one published in Beilstein, Journal of Organic Chemistry.

Education

  • Ph.D. Organic Chemistry, Institute of Organic Chemistry, University of Tubingen, Germany
  • M.Sc. University Paul Sabatier, Toulouse, France
  • B.Sc. University Paul Sabatier, Toulouse, France
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