Protein Engineering and DNA Repair Expert Specializing in Directed Enzyme Evolution

Technical Consultant #1633


Expertise

  • Random mutant library generation.
  • Protein engineering.
  • Mutagenicity assays, (Ames' test).
  • ColE1-based plasmid regulation.
  • DNA repair, specifically repair of reactive DNA methylation.
  • Drug resistance: targets, evolution.
  • Microbial genetics.
  • Molecular pharmacology.
  • Molecular toxicology.

Experience

Undisclosed University, Assistant Professor, 2007 - Present

  • Head of a research team including a senior scientist, technician, graduate student and several undergraduate assistants.
  • Obtained extramural funding from NIH and private foundations.
  • Ongoing interdisciplinary collaborations in areas of computational biology, chemistry and structural biology.
  • Partnership with industry (Environmental Biodetection Products Inc.) for bringing new mutagenesis detection technology into the market.
  • Teaching in areas of molecular toxicology and pathogenesis.

University of Washington, Seattle, WA, 2001 - 2007

  • Acting Instructor: Applied directed evolution methods for customization of DNA methylation repair.
  • Postdoctoral Fellow: Developed a proprietary system for directed protein evolution.

Stanford University School of Medicine, Microbiology and Immunology, Stanford, CA, 1994 - 2001

  • Graduate Research Assistant

University of Barcelona, Department Biochemistry/Autonomous, Bellaterra, Spain, 1991 - 1994

  • Masters Research Assistant/Mentor
  • Undergraduate Research Assistant/Mentor

Teaching Experience

  • Classes: Biology of Disease, Interdisciplinary approaches in microbiology and environmental toxicology.

Honors & Publications

Honors and Awards

  • CONCERN Foundation Award for cancer research: Title, "Customizing DNA Repair to Reduce the Side Effects of Temozolomide."
  • National Cancer Institute K08 award (top priority score of 117): Title, "Creation of AlkB Mutants for Bone Marrow Protection."
  • Environmental Pathology/Toxicology Training Grant (T32 NIEHS National Research Service Award Program).
  • Stanford Dean of Research Incentive Fund Award.
  • "la Caixa" Fellowship, participant of the Fullbright program in Spain.
  • Top Student of Graduating Class of Veterinary School of the Autonomous University of Barcelona, Bellaterra, Spain.

Synergistic Activities

  • Memberships: Environmental Mutagen Society, Society of Toxicology
  • Editorial board: Theoretical Biology Insights
  • Referee: Cellular and Molecular Life Sciences, Journal of Molecular Evolution

Credentials

  • Doctor in Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain

Publications

  • Numerous invited talks, selected meeting presentations and articles published.
  • Two U.S. Patents.

Education

  • Ph.D. Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
  • M.S. Biochemistry, Autonomous University of Barcelona, Bellaterra, Spain
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