Industrial Microbiology Consultant: Microbial Fermentation, Microbial Physiology and Protein Production

Technical Consultant #1580


Expertise

  • Microbial physiology and biochemistry.
  • Microbial fermentation development for natural products, anti-infectives, whole-cell biocatalysis and heterologously expressed proteins.
  • Development of high-throughput microbial screening platform.
  • Cell culture for producing therapeutic proteins by transient transfection.
  • Diverse bioprocess development in microbial strain improvement using classical techniques and automated screening.

Experience

Undisclosed Company, Owner/President, 2008 - Present

  • Industrial microbiology, fermentation and biotechnology consulting.
  • Therapeutic protein laboratory production.
  • Business and product development from the end-user point of view.
  • Subject matter expert on microbial technology for document review and due diligence.

Merck Research Labs, Bioprocess Research and Development, Rahway, NJ, Senior Investigator, 1991 - 2008

  • Established and led a small scale protein production team which provided 10 - 100 mg of preclinical therapeutic proteins for evaluation.
  • Utilized transient transfection, hybridoma cultivation, and Pichia pastoris expression systems.
  • Led microbial fermentation and strain improvement efforts for a variety of anti-bacterial, anti-fungal, statins, ion-channel inhibitors, and immunoregulant natural products produced by actinomycetes and filamentous fungi.
  • Led development of the Glarea lozoyensis fermentation process for producing "Cancidas" caspofungin acetate, first in class systemic anti-fungal.
  • Established a robust, high-throughput (1000 - 2000) microbial screening platform using 24 deep well plates, commercially available liquid handing equipment (TECAN), bioassays where applicable, and high-throughput HPLC.
  • Whole-cell biocatalysis for the production of chiral intermediates.
  • Pseudomonas putida dioxygenase bioconversion process converting indene to the corresponding chiral diol, an intermediate in "Crixivan" indinavir sulfate.
  • Oversaw outsourcing of R&D activities to US and emerging market vendors.

Honors & Publications

Academic and Professional Affiliations

  • Editorial Board, Journal of Industrial Microbiology and Biotechnology
  • Editorial Board, Enzyme and Microbial Technology
  • Board of Directors, Society for Industrial Microbiology
  • Program Chair, Society for Industrial Microbiology Annual Meeting and Exhibition
  • Program Chair, Recent Advances in Fermentation Technology (RAFT V)

Publications

  • Contributing author on numerous peer-reviewed papers and book chapters.
  • Conference abstracts.

Patents

  • 3 U.S. Patents.

Education

  • Ph.D. Microbiology, The Ohio State University, Columbus, OH
  • B.S. Biology (Chemistry Minor), Norwich University, Northfield, VT
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