Oncology Medicinal Chemistry Consultant: Cancer and Autoimmune Disease Drug Discovery and Development

Technical Consultant #1480

Cancer drug discovery researcher with pharmaceutical industry and academic research experience in the field of cancer and autoimmune diseases.
Research experience in various in vitro/in vivo cancer biology and molecular biological techniques such as; ELISA, siRNA, qPCR, Western Blot, Apoptosis, Cell-Cycle Analysis, microscopic techniques and in vitro angiogenesis.
Pathway and drug mechanism analysis using PCR- arrays and si-RNA arrays.
Inventor with 15 patent applications in the field of cancer drug discovery and novel p38 inhibitors as anti-autoimmune diseases agents, and in the design, discovery and development of bio devices for use in clinics, pathological laboratories and research centers.
Ovarian and neuroblastoma xenograft in vivo animal models to evaluate efficacy and safety of the new cytotoxic agents synthesized by this consultant and laboratory.
Supervised and trained M.S. medicinal chemists.
Inventor of three different class of novel preclinical anticancer agents (MT-19c and Fe-SP) and Nifurtimox undergoing Phase-II clinical trials for childhood neuroblastoma.

Undisclosed University Hospital, Advisor, 2003 - Present

Associate Research Scientist: Molecular Therapeutics Laboratory, Gynecology and Oncology.
Post-Doctoral Research Associate: Molecular Therapeutics, Laboratory, Dept. Pediatrics and Gynecology and Oncology.

Ranbaxy Research laboratories, Division of Medicinal Chemistry, Gurgaon, India, 1997 - 2002

New Drug Discovery Research

Research Scientist: Design and synthesis of novel p38 inhibitors as anti-inflammatory agents. Synthesized many series of multiple step synthetic strategies leading to a pre clininal candidate with desired ADME properties. Designed solution phase parallel libraries incorporating various parameters including Lipinski's Rule, lipophilicity and ADME.
Research Associate: Related to p38 inhibitors, participated in designing and synthesizing many series of multiple step synthetic strategies leading to a few low nM compounds with desired ADME properties.
Research Fellow: Design and synthesis of novel p38 inhibitors as anti-inflammatory agents. Project: Activated lactams in Organic Synthesis and Molecular Diversity Generation.

Birla Institute of technology and Science, Pilani, India, 1993 - 1997

Technical Assistant: Dept of Chemistry, chemistry and laboratory instructor for undergraduates:
Taught chemistry and laboratory classes.
Laboratories development and supervison.
Pursue studies towards higher degree in Chemistry in the Medicinal Chemistry in Department of Pharmacy.

Lark laboratories, Okhla, New Delhi, Quality Control Chemist, 1992 - 1993

Analysis of the active pharmaceutical (API) content in both solid and liquid drug formulations.
Development and standardization of newer protocols for API analysis in drug formulations.
Compliance as per the US pharmacopeia (USP), Indian Pharmacopeia (IP) and other compliant regulations such as WHO - GMP.

Publications

Author of 16 peer reviewed articles (11 as primary) and 15 patent applications in the field of cancer drug discovery and novel p38 inhibitors as anti-autoimmune diseases agents.
Several journals for articles.
15 patents.

Ph.D. Division of Medicinal Chemistry, Ranbaxy Research Laboratories, New Delhi,India
MPhil Department of Pharmacy, Birla institute of technology and Science, India
M.Sc. Department of Chemistry, Purvanchal University, Jaunpur, India.
B.Sc. Industrial Chemistry, Delhi University, India.